It has also been shown that Reed-Sternberg cells and mononuclear-variant cells produce IL-6.[11]One report says of 19 cases with both HL and CD, that the diagnosis of Hodgkin's disease was delayed in 16 cases.[3] The Castleman-like changes induced by IL-6 can make it harder for the pathologist to recognize the diagnostic Reed-Sternberg cells, and consequently, the diagnosis of a very treatable disease may then be missed.[3–7] Our series included one case (case 1) of interfollicular HL that was diagnosed concurrently in a mediastinal lymph node. Here, IL6 is linked to Hodgkins lymphoma.