PLK1 and non-small cell lung carcinoma: Recently it has been shown that the effects of TQ are broad with the demonstration that TQ inhibits Polo like kinases (PLKs) [27], family of serine/threonine protein kinases which control critical steps in passage of cells through the M phase of the cell cycle [28].Also PLK1 is over expressed in NSCLC and has prognostic significance [29].