FGF23 and chronic kidney disease: Currently, therapy with phosphate binders is recommended to correct hyperphosphatemia; prospective, randomized long-term trials need to be conducted in patients with CKD stages 2 to 4 to evaluate whether phosphate binders could lead to a sustained reductions in serum FGF-23 levels and whether such reductions would prolong kidney and patient survival and prevent the development of secondary hyperparathyroidism, as predicted by earlier studies.