GPT and acute liver failure: To further elucidate the hepatoprotective effects of broad spectrum MMP-inhibition, we dosed Marimastat-pretreated C57Bl/6J mice with a single injection of CCl4, to demonstrate reduced centrilobular necrosis and a marked (57%) reduction in serum ALT levels corroborating the hepatoprotective effects of Marimastat also in acute liver failure.