Future experiments will be needed to investigate whether the aberrant activation of iNKT cells seen in murine prostate tumors can be observed in advanced prostate cancer patients Notably, like human prostate tumors and CaP cell lines [25], [26], TRAMP prostate tumor cells secrete high amounts of the chemokine CCL2 and attracted iNKT cells into the TME without detectable depletion of iNKT cells elsewhere. Here, CCL2 is linked to prostate cancer.