We have assessed genetic variants (SNPs) in lipoxygenase pathway genes for evidence of association with markers of subclinical atherosclerosis (intima-media wall thickness [IMT], carotid artery calcified plaque [CarCP], coronary artery calcified plaque [CorCP], and aortic calcified plaque [AorCP]) and biomarkers (e.g., ICAM-1, E-selectin, CRP) in participants of the Diabetes Heart Study (DHS). The gene discussed is SELE; the disease is atherosclerosis.