Increasing or decreasing extracellular WNT5A levels had little impact on β-catenin nuclear location and β-catenin/TCF-dependent transcription (Figure 4C and 4D), suggesting that the canonical Wnt-dependent role of ROR2 epigenetic deregulation in DLD1 colon cancer cells does not necessarily require WNT5A. Here, ROR2 is linked to malignant colon neoplasm.