To determine whether the canonical Wnt-dependent role of aberrant epigenetic repression of ROR2 in colon cancer is WNT5A-associated, we used we used a dual approach: i) we increased extracellular levels using recombinant WNT5A protein and ii) we used anti-WNT5A antibody to greatly reduce WNT5A activity in DLD1 cells expressing ROR2 and control cells. Here, WNT5A is linked to colonic neoplasm.