As ROR2 is reported to mediate the WNT5A-dependent inhibition of β-catenin-TCF-regulated genes in human embryonic cells [8,15], we tested whether WNT5A mediated the canonical Wnt-dependent role of aberrant epigenetic ROR2 repression in colon cancer. The gene discussed is WNT5A; the disease is malignant colon neoplasm.