The oncofetal protein IMP3 plays an important role in translational control of Insulin-like Growth Factor II leader-3 mRNA during proliferation and in cell-adhesion [1,3,28] and it regulates, among others, CD24 and CD166, both of which we have identified as prognostic markers for prostate cancer in earlier studies [1,29]. Here, IGF2 is linked to Familial prostate cancer.