His kidney function was slightly impaired with an estimated glomerular filtration rate (GFR) of 71 mL/min/1.73 m2 (abbreviated modification of diet in renal disease (MDRD) formula), a moderate leukocytosis (10,700/mm3) and slight elevation of C-reactive protein (CRP) (1.9 mg/dL), besides elevated plasma concentrations of lactate dehydrogenase (639 U/L). The gene discussed is CRP; the disease is Increased total leukocyte count.