After experimental sporozoite infection of naïve volunteers, donor responses could be divided equally into those who produced moderate levels of IFN-γ and IL-10 with no IL-12p70, those who produced detectable IL-12p70 and high levels of IFN-γ and IL-10 and those who produced high levels of TGFβ in the absence of a pro-inflammatory response (4), providing further evidence for the existence of donor-dependent malaria-specific cytokine responses. This evidence concerns the gene IFNG and malaria.