INS and type 2 diabetes mellitus: In the INSIGHT study [29] (implementing New Strategies with Insulin Glargine for Hyperglycaemia Treatment), type 2 diabetic patients (HbA1C levels 7.5–11.0%) on stable therapy with 0–2 OADs, not including thiazolidinediones, were randomized to either an optimised OAD regimen (with no insulin) or initiation of bedtime glargine (with no increase in the oral therapy).