Mazières et al (2004) demonstrated in a study on human lung cancer tissues, a correlation between RhoB loss of expression and a worse tumour stage. These data suggest that RhoB is implicated in the regulation of malignant transformation and progression. Moreover, Jiang et al (2004) identified suppression of RhoB as a mechanism inducing tumour metastasis. The gene discussed is RHOB; the disease is lung cancer.