Two recent autopsy series have shown that the incidence of GIST may be as high as 50% in stomach specimens (Kawanowa et al, 2006; Agaimy et al, 2007); in one of these series, canonical KIT or PDGFRA mutations were found in 50% of assessable tumours (Agaimy et al, 2007). The gene discussed is PDGFRA; the disease is neoplasm.