In this manuscript, we present a computational approach to classify DF and DHF patients based on mRNA expression data of 11 genes (MYD88, MDA5, TLR3, TLR7, TLR9, IRF3, IRF7, IFN-α, IFN-β, IFN-γ, and RIGI) involved in the innate immune response pathway using the support vector machines (SVM) algorithm. Here, IRF3 is linked to Dengue hemorrhagic fever.