Cohorts of male control (Brca2F/F;Trp53F/F), Brca2 homozygous and Trp53 heterozygous (Brca2F/F;Trp53F/+;PBCre4) and Brca2 and Trp53 double homozygous (Brca2F/F;Trp53F/F;PBCre4) animals were generated and analysed for tumour progression. This evidence concerns the gene BRCA2 and neoplasm.