Diffusion and progression are further influenced by autocrine and paracrine production of cytokines [12] such as, for example, Transforming Growth Factor (TGF) beta, Hepatocyte Grow Factor (HGF), Fibroblast Growth Factor (FGF), Vascular Endothelial Growth Factor (VEGF) A, and Vascular Endothelial Growth Factor (VEGF) C. These growth factors are very important for melanoma progression, because they support cell survival and enhance metastatic potential, creating a microenvironment that promotes growth and tumor expansion [13, 14]. The gene discussed is VEGFA; the disease is neoplasm.