At least 12 different genes or chromosomal loci have been associated with the autosomal-dominant or recessive types of ARVC so far, including all five known desmosomal genes expressed in cardiomyocytes (i.e., DSG 2, DSC 2, DSP, JUP, and PKP 2). The gene discussed is DSP; the disease is Arrhythmogenic right ventricular dysplasia.