To determine whether the Wave2 signaling complex and Abl are required exclusively for HIV-1 entry, or virus-induced fusion and infection in general, we examined infection with HIV-1 versus A-MLV Env (A-MLV-ENV-HIV-1) or VSV-G pseudotyped HIV-1 (VSV-G-HIV-1) using the TZM-BL assay. The gene discussed is ERVW-1; the disease is infection.