In the results reported here, we show that RELA (p65 subunit of NF-κB) and STAT5 are the major proteins associated with carboplatin resistance in ovarian cancer, and show that they both bind the promoter and act synergistically to induce the expression of Bcl-xL, the molecular convergence point of the NF-κB and STAT5 pathways. This evidence concerns the gene STAT5B and ovarian cancer.