S100B and manic or hypomanic episode: For major depressive and manic episodes, values were significantly higher than zero, confirming high serum S100B in acute episodes of mood disorder (T = 6.4, = 17, df = 2, = 1, P = .024, = .037; 2-tailed Student's t-test against 0), which was not the case for currently euthymic mood disorder (T = 1.4, df = 1, P > .05).