While the expression pattern of Prox1 in our model does not fully recapitulate the GFP expression found in the Tie1-GFP mouse model, it is clear that when Prox1 is overexpressed in our tissue specific model it results in aberrant lymph sac development, hemorrhaging, edema, anemia and ultimately, embryonic lethality. This evidence concerns the gene TIE1 and anemia (phenotype).