DTL, ECT2, MTDH, PRC1 and RFC4 have all been previously implicated in breast cancer; SCUBE2 and STK32B deletions have been found to be related to mental deficits in humans; and ZNF533 has been found to be associated with the Hedgehog signaling pathway in Zebrafish [26-35]. The gene discussed is DTL; the disease is breast cancer.