In a univariate Cox model, MED28 as a continuous variable was not a significant predictor of tumor recurrence (P = 0.113); however, when we dichotomized expression levels, MED28 was a significant predictor, with relatively higher levels of MED28 expression predicting a significantly greater chance of breast cancer recurrence than those with lower MED28 expression (Figure 4A; P = 0.027). Here, MED28 is linked to breast cancer.