Recent works also studied other potential markers in relation to polyp characteristics: for the serum sulfatase activity, differences regarding the number of adenomas (single or multiple) were significant [23]; serum leptin, adiponectin and resistin also differed between controls and patients with adenomas or CRC, though there was no relationship with dysplasia, histopathology or polyp localization [24]. This evidence concerns the gene RETN and adenoma.