Recent studies have revealed that several genes and molecules are involved in the origin and/or progression of esophageal cancer, including TP53 [1,2], deleted in esophageal cancer 1(DEC1) [3], deleted in colorectal cancer (DCC) [4], deleted in lung cancer 1(DLC1) [5], cyclinD1 [6,7], transforming growth factor-beta receptor type II (TGFBRII) [8], adenomatous polyposis coli (APC) [9,10], survivin [11], and murine double minute 2 (MDM2) [12]. This evidence concerns the gene APC and esophageal cancer.