However, assignment of HER-2 grade by assessment of IHC is inherently subjective and dependent on the skill and experience of the reviewing pathologist.31 Thus the standardization of diagnosing breast cancer is a very important task for improving personalized cancer patient care, as a cancer patient to whom an inappropriate drug is given will face disease progression during the treatment time impacting on overall survival rate and increased costs.32 The gene discussed is ERBB2; the disease is breast cancer.