This is supported by a limited number of studies showing that PDGFR inhibition by Imatinib not only reduces fibroblast proliferation in vitro [8] but also slows progression of cervical carcinomas [9], growth of pancreatic carcinomas [10], progression and metastasis of colon carcinomas [7], and improves the uptake of radioimmunotherapy in colorectal carcinomas [11]in vivo. The gene discussed is PDGFRB; the disease is colorectal carcinoma.