Multivariate analysis showed that the expected cancer-free survival time was 20.4375 ± 7.28648 m for tumors with HMGB1 overexpression (95% CI = 17.8104 - 23.0646), 15.5870 ± 8.23158 m for tumors with HMGB1 no-and low-level expression (95% CI = 13.1425 - 18.0314). This evidence concerns the gene HMGB1 and cancer.