For example, ENC-1, often over-expressed in some types of leukemia [38], KLF12, a transcription factor associated with progression of gastric cancer [39], and CDC42EP2, a small Rho GTPase binding protein involved in hypoxia-induced angiogenesis [40], were induced by gefitinib at 24 h treatment. This evidence concerns the gene KLF12 and gastric cancer.