In this study we investigated the association of GRIA1, GRIA2, GRIA3 and GRIA4 genes that encode for the four subunits (GluR1-GluR4) of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) ionotropic receptor and their variants to migraine with and without aura (MA and MO). This evidence concerns the gene GRIA3 and migraine disorder.