Because of the obscure and variable behavior of cancer, this study concerned different aspects of tumor dynamics through the immunohistochemcial evaluation of EGFR expression in OSCC and its correlation with proliferation, apoptosis, angiogenesis and lymphangiogensis via evaluating PCNA, p53, VEGF and D2- 40 Mabs immunohistochemically. This evidence concerns the gene EGFR and cancer.