The pro-apoptotic effects of FLLL32 (Figure 1A) were examined by flow cytometry following Annexin V/PI staining of a panel of metastatic human melanoma cell lines with basal STAT3 phosphorylation (A375, Hs294T, FO1, HT144, MEL-39) and the pSTAT3 negative 1106 MEL and 1259 MEL cell lines [17]. The gene discussed is ANXA5; the disease is melanoma.