Numerous early generation small molecule STAT3 inhibitors (e.g. Stattic, STA-21, LLL12, S32 M2001, S3I-201) have been reported to induce apoptosis via inhibition of STAT3 activation and/or dimerization [33,37], while siRNA specific for the SH2 coding region of STAT3 could induce apoptosis in prostate cancer cells in vitro and in nude mice bearing human xenograft tumors [32]. The gene discussed is STAT3; the disease is prostate cancer.