These findings strongly suggest that potent inflammatory lipid mediators such as PAF and its receptor (PAFR) are not only involved in cancer progression and metastasis, but they are also significantly involved in early malignant transformation through phosphor-FAK/STAT1 networking and anti-apoptosis pathway in BRCA1-mutant dysfunctional at-risk ovarian epithelium. The gene discussed is PTK2; the disease is cancer.