In contrast, CAT2 was recently shown to have an important, host-protective role in parasitic infestation models [9], similar to studies which demonstrated a role for arginase expression in host defense in models of parasite infestation (including Schistosome mansoni, Heligmosomoides polygyrus, Leishmania sp, Toxoplasma gondii and Nipostrongylus brasiliensis) [21-26]. The gene discussed is SLC7A2; the disease is parasitic infectious disease.