TP53 and neoplasm: However, the effect of inhibition of PPM1D on tumor cell growth and drug sensitivity is not limited to tumor cells that harbor these amplifications as we observed synergistic or additive activity of CCT007093 with paclitaxel in TNBC cell lines (MDA-MB-231 and MDA-MB-468, mutant p53 cell lines) including some paclitaxel-resistant lines.