UGCG and Insulin resistance: We have previously shown that a small molecule inhibitor of glucosylceramide synthase (GCS), the initial and rate-limiting enzyme involved in the biosynthesis of gangliosides and other glycosphingolipids (GSLs), improved glycemic control, decreased insulin resistance, and inhibited the development of hepatic steatosis in several animal models of type 2 diabetes [9], [10].