ZNF224 and Cognitive impairment: Indeed, when we substituted a term for neurofibrillary tangles instead of the global pathology variable in our regression model, the effect of the ZNF224 variant on global cognition was reduced by 64%, and was no longer significant (Beta = −0.14, p = 0.21), whereas tangles showed a robust association with cognitive impairment (p<2×10−16).