Using the optimal dominant model of inheritance, the ZNF224 SNP (rs3746319) explained an additional 2% (Beta = 0.13, p = 0.003) of the residual variance in global AD pathology and 2.1% (Beta = −0.39, p = 0.002) of the variance in global cognition (Table 6). This evidence concerns the gene ZNF224 and Alzheimer disease.