CD8A and cancer: In this study, we have constructed a prototype HER-2 glyco-lipopeptide (HER-GLP) cancer vaccine by incorporating all the necessary components, including TACA as B cell epitopes, CD4+ and CD8+ T cell peptide epitopes and an internal immuno-adjuvant (palmitic acid) in one construct in order to boost potent and specific antitumor B and T cell immunity.