As heparin, LMWHs and heparin derivatives can abolish the activity or binding of heparanase [17], [18] and hyaluronidase [19] by competing with heparan sulphates and hyaluronan [20]–[22], it has been hypothesized that LMWHs (at least in part) limit cancer progression by restoring cancer cell-induced glycocalyx damage thereby limiting cancer cell extravasation [23]. The gene discussed is HPSE; the disease is cancer.