CHRNA7 and Cognitive impairment: Furthermore, we reported that tropisetron or the selective α7 nAChR agonist SSR180711, but not the selective 5-HT3 receptor antagonist ondansetron, could ameliorate phencyclidine (PCP)-induced cognitive deficits in mice, and that the effects of tropisetron or SSR180711 were blocked by coadministration of MLA [21,22].