Taken together, given LRP5 is a co-receptor of Frizzled-4 receptor [43], these studies suggest that the Frizzled-4/LRP5 mediated β-catenin/TCF4 pathway may participate in regulation of the EMT process in PCa progression and that WIF1 may interfere with Wnts/Frizzled-4 or LRP5 interaction leading to a reversal of EMT. The gene discussed is FZD4; the disease is posterior cortical atrophy.