In addition, the area under the ROC curves for total adiponectin and HMWA were not significantly different for the identification of metabolic abnormalities; obesity (total adiponectin 0.592 [95% CI 0.510-0.673] vs. HMWA 0.610 [95% CI 0.531-0.690], P = 0.32); hypertriglyceridemia (total adiponectin 0.661 [95% CI 0.596-0.726] vs. HMWA 0.671 [95% CI 0.607-0.736], P = 0.504); and hypoalphalipoproteinemia (total adiponectin 0.624 [95% CI 0.555-0.692] vs. HMWA 0.633 [95% CI 0.564-0.702], P = 0.582). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.