PRM2 and hyperinsulinemic hypoglycemia, familial, 4: When the membranes were blotted with Hub2B antibody recognizing mature protamine 2, the same pattern of decreasing levels of the mature form with increasing NPYq deficiency was observed, there being no reduction in 2/3NPYq-, a 12% reduction in 9/10NPYq- (P = 0.00005) and a 44% reduction in NPYq-2 males (not significant) (Figure 10b, Table 2).