TNF and ablepharon macrostomia syndrome: Thus taking macrophage and mast cell-associated TNFα together, approximately 100% of islet TNFα was localized to mast cells or macrophages in the subset of AMS patients studied, while in the islets of the subset of BMS patients studied, only 28% of TNFα immunoreactivity was localized to these cells (Table 3) (p < 0.001).