They provide growth factors, proangiogenic factors, proteases, and adhesion molecules that facilitate tumor cell proliferation, angiogenesis, invasion, and metastasis.(7,8) Of the chemokines and chemokine receptors in inflammatory cell recruitment, stromal-derived factor 1 (SDF-1 or CXCL12) is considered one of the key regulators of hematopoietic stem and progenitor cell trafficking between the peripheral circulation and targeted tumor tissues. This evidence concerns the gene CXCL12 and neoplasm.