VEGFA and metastatic colorectal cancer: The approval of bevacizumab, a humanized monoclonal antibody that recognizes and blocks vascular endothelial growth factor A (VEGFA), by the US Food and Drud Administration as a first-line therapy for metastatic colorectal cancer validates the ideas that VEGF is a key mediator of tumor angiogenesis and that blocking angiogenesis is an effective strategy to treat human cancer.(1–3)