Reiners et al. (1999) reported that cell proliferation was also inhibited in the murine hepatoma cell line 1c1c7 by flavone and α-naphthoflavone treatment and in AhR-KO cells. Moreover, mouse embryonic fibroblasts from AhR-KO mice grew more slowly than did wild-type cells (Elizondo et al. 2000). The gene discussed is AHR; the disease is hepatocellular carcinoma.