GRIN2B and spindle cell hemangioma: However, when cultured PFC neurons were pretreated by D1 antagonist SCH-23390 followed by SKF-81297 administration, the enhancement in NR2B expression was significantly attenuated (puncta number: 21.8 ± 1.10 in SKF + SCH, n = 25, p < 0.001; fluorescence intensity: 30,544 ± 2504 in SKF + SCH, n = 25, p < 0.001; Figure 2A and 2B).