EZR and familial pancreatic carcinoma: Although a recent study has shown that overexpression of pEzrin(Tyr353) in pancreatic cancers is associated with positive lymph node metastasis, less differentiation, pAkt overexpression, and shorter survival times [27], we did not observe any change of ezrin phosphorylation in either the ezrin overexpressing or the ezrin silencing MiaPaCa-2 cells.