IGF1R and central nervous system cancer: Although, we still do not fully understand how anti-atherosclerotic effects of fenofibrate could be related to its action against Glioma cell motility, its wide spectrum of lipid modifying actions, including strong activation of fatty acid β-oxidation, inhibition of glycolysis [16,23] and ROS accumulation [24,25], as well as inhibition of the IGF-IR signal transduction [12], all require further examination.