Our study clearly suggest that preoperative chemotherapy alters the expression of and relationships among several hypoxia-related proteins, specifically, HIF-1α and leptin in primary and metastatic tumors, HIF-1α and ObR in metastatic tumors, HIF-1α and Glut-1 in primary tumors; Glut-1 and ERβ in primary tumors; Glut-1 and Ki-67 in primary and metastatic tumors. Here, ESR2 is linked to metastatic neoplasm.